A 50-truck convoy departed from Turkey’s southern border province of Hatay and headed to Syria’s Aleppo and Idlib provinces, IHH Secretary General Yavuz Dede said.
Last month, a UN aid convoy was attacked as it was about to enter Aleppo, where 275,000 civilians need humanitarian assistance.
The attack in Urum al-Kubra, west of Aleppo, killed the head of the Syrian Arab Red Crescent, as well as aid staff and drivers in a 31-truck convoy.
Syria has been locked in a vicious civil war since early 2011 when the regime of Bashar al-Assad cracked down on pro-democracy protests.
The Syrian Center for Policy Research, a Beirut-based NGO, has put the total death toll from the five-year conflict at more than 470,000.